Predictive Value of Myocardial injury in Patients with COVID-19 Admitted to a Quaternary Hospital in the City of Rio de Janeiro

Abstract Background In Brazil the factors involved in the risk of death in patients with COVID-19 have not been well established. Objective To analyze whether elevations of high-sensitivity troponin I (hTnI) levels influence the mortality of patients with COVID-19. Methods Clinical and laboratory characteristics of hospitalized patients with COVID-19 were collected upon hospital admission. Univariate and binary logistic regression analyzes were performed to assess the factors that influence mortality. P-value<0.05 was considered significant. Results This study analyzed192 patients who received hospital admission between March 16 and June 2, 2020 and who were discharged or died by July 2, 2020. The mean age was 70±15 years, 80 (41.7%) of whom were women. In comparison to those who were discharged, the 54 (28.1%) who died were older (79±12 vs 66±15years; P=0.004), and with a higher Charlson´s index (5±2 vs 3±2; P=0.027). More patients, aged≥60years (P <0.0001), Charlson´s index>1 (P=0.004), lung injury>50% in chest computed tomography (P=0.011), with previous coronary artery disease (P=0.037), hypertension (P=0.033), stroke (P=0.008), heart failure (P=0.002), lymphocytopenia (P=0.024), high D-dimer (P=0.024), high INR (P=0.003), hTnI (P<0.0001), high creatinine (P<0.0001), invasive mechanical ventilation (P<0.0001), renal replacement therapy (P<0.0001), vasoactive amine (P<0.0001), and transfer to the ICU (P=0.001), died when compared to those who were discharged. In logistic regression analysis, elevated hTnI levels (OR=9.504; 95% CI=1.281-70.528; P=0.028) upon admission, and the need for mechanical ventilation during hospitalization (OR=46.691; 95% CI=2.360-923.706; P=0.012) increased the chance of in-hospital mortality. Conclusion This study suggests that in COVID-19 disease, myocardial injury upon hospital admission is a harbinger of poor prognosis.

Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report.

BACKGROUND: Herein, we aimed to follow up on the cellular and humoral immune responses of a group of individuals who initially received the CoronaVac vaccine, followed by a booster with the Pfizer vaccine. METHODS: Blood samples were collected: before and 30 days after the first CoronaVac dose; 30, 90, and 180 days after the second CoronaVac dose, and also 20 days after the booster with the Pfizer vaccine. RESULTS: Whilst the positivity to gamma interferon-type cellular response increased after the first CoronaVac dose, neutralizing and IgG antibody levels only raised 30 days after the second dose, followed by a drop in these responses after 90 and 180 days. The booster with the Pfizer vaccine elicited a robust cellular and humoral response. A higher number of double-negative and senescent T cells, as well as increased pro-inflammatory cytokines levels were found in the participants with lower humoral immune responses. CONCLUSION: CoronaVac elicited an early cellular response, followed by a humoral response, which dropped 90 days after the second dose. The booster with the Pfizer vaccine significantly enhanced these responses. Furthermore, a pro-inflammatory systemic status was found in volunteers who presented senescent T cells, which could putatively impair the immune response to vaccination.

COVID-19 and isolation: Risks and implications in the scenario of new variants.

With the emergence of new variants of SARS-CoV-2, questions about transmissibility, vaccine efficacy, and impact on mortality are important to support decision-making in public health measures. Modifications related to transmissibility combined with the fact that much of the population has already been partially exposed to infection and/or vaccination, have stimulated recommendations to reduce the isolation period for COVID-19. However, these new guidelines have raised questions about their effectiveness in reducing contamination and minimizing impact in work environments. Therefore, a collaborative task force was developed to review the subject in a non-systematic manner, answering questions about SARS-CoV-2 variants, COVID-19 vaccines, isolation/quarantine periods, testing to end the isolation period, and the use of masks as mitigation procedures. Overall, COVID-19 vaccines are effective in preventing severe illness and death but are less effective in preventing infection in the case of the Omicron variant. Any strategy that is adopted to reduce the isolation period should take into consideration the epidemiological situation of the geographical region, individual clinical characteristics, and mask for source control. The use of tests for isolation withdrawal should be evaluated with caution, due to results depending on various conditions and may not be reliable.

Assessing clinical applicability of COVID-19 detection in chest radiography with deep learning.

The coronavirus disease 2019 (COVID-19) pandemic has impacted healthcare systems across the world. Chest radiography (CXR) can be used as a complementary method for diagnosing/following COVID-19 patients. However, experience level and workload of technicians and radiologists may affect the decision process. Recent studies suggest that deep learning can be used to assess CXRs, providing an important second opinion for radiologists and technicians in the decision process, and super-human performance in detection of COVID-19 has been reported in multiple studies. In this study, the clinical applicability of deep learning systems for COVID-19 screening was assessed by testing the performance of deep learning systems for the detection of COVID-19. Specifically, four datasets were used: (1) a collection of multiple public datasets (284.793 CXRs); (2) BIMCV dataset (16.631 CXRs); (3) COVIDGR (852 CXRs) and 4) a private dataset (6.361 CXRs). All datasets were collected retrospectively and consist of only frontal CXR views. A ResNet-18 was trained on each of the datasets for the detection of COVID-19. It is shown that a high dataset bias was present, leading to high performance in intradataset train-test scenarios (area under the curve 0.55-0.84 on the collection of public datasets). Significantly lower performances were obtained in interdataset train-test scenarios however (area under the curve > 0.98). A subset of the data was then assessed by radiologists for comparison to the automatic systems. Finetuning with radiologist annotations significantly increased performance across datasets (area under the curve 0.61-0.88) and improved the attention on clinical findings in positive COVID-19 CXRs. Nevertheless, tests on CXRs from different hospital services indicate that the screening performance of CXR and automatic systems is limited (area under the curve < 0.6 on emergency service CXRs). However, COVID-19 manifestations can be accurately detected when present, motivating the use of these tools for evaluating disease progression on mild to severe COVID-19 patients.

Impact of COVID-19 Disease in Early Breast Cancer Management: A Summary of the Current Evidence.

PURPOSE: An expert panel on breast cancer and COVID-19 disease was convened to address the impact of the COVID-19 pandemic for early breast cancer (eBC) management. METHODS: To ensure that the most clinically relevant information was addressed, essential information was drawn from several of the latest national and international guidelines and another technical document. The expert panel met in five virtual closed sessions from November 2020 to May 2021 to consult on the relevant data from evidence-based results. The data gathered were discussed on an online platform. RESULTS: This article reports the expert panel's highlights of these meetings' discussions. In addition, it provides practical recommendations covering topics regarding diagnosis, treatment, and management of patients with eBC in clinical settings routinely encountered by health care professionals amid the COVID-19 pandemic. CONCLUSION: This article provided guidance on several topics regarding eBC management amid the COVID-19 pandemics to inform safer care practices.

Challenges of Post-COVID-19 for a Sustainably Developed Society

The COVID-19 pandemic has prompted both preventive and reactive disease control measures, such as lockdown, physical distancing, and mask use, among others [...]

Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future.

A plethora of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic tests are available, each with different performance specifications, detection methods, and targets. This narrative review aims to summarize the diagnostic technologies available and how they are best selected to tackle SARS-CoV-2 infection as the pandemic evolves. Seven key settings have been identified where diagnostic tests are being deployed: symptomatic individuals presenting for diagnostic testing and/or treatment of COVID-19 symptoms; asymptomatic individuals accessing healthcare for planned non-COVID-19-related reasons; patients needing to access emergency care (symptom status unknown); patients being discharged from healthcare following hospitalization for COVID-19; healthy individuals in both single event settings (e.g. airports, restaurants, hotels, concerts, and sporting events) and repeat access settings (e.g. workplaces, schools, and universities); and vaccinated individuals. While molecular diagnostics remain central to SARS-CoV-2 testing strategies, we have offered some discussion on the considerations for when other tools and technologies may be useful, when centralized/point-of-care testing is appropriate, and how the various additional diagnostics can be deployed in differently resourced settings. As the pandemic evolves, molecular testing remains important for definitive diagnosis, but increasingly widespread point-of-care testing is essential to the re-opening of society.

The Role of Serology Testing in the Context of Immunization Policies for COVID-19 in Latin American Countries.

This review aims to explore the role and value of serology testing in the context of COVID-19 immunization policies in Latin American countries and the barriers and challenges to the adequate use and uptake of this tool. It builds on a review of the academic literature, evidence, and existing policies, and includes a multistage process of discussion and feedback by a group of five experts. Regional and country-level evidence and resources from five focus countries-Argentina, Brazil, Chile, Colombia, and Mexico-were collected and analyzed. This review contains an overview of (1) the impact of the SARS-CoV-2 pandemic, the variants of concern and current testing strategies, (2) the introduction of COVID-19 vaccination, (3) the potential use of serology testing to support immunization initiatives, (4) the current frameworks for the use of serology testing in the region, and (5) the barriers and challenges to implementing serology testing in the context of COVID-19 immunization policies, including a discussion on the potential actions required to address these barriers and facilitate the uptake of this strategy in the region. Stakeholders can use elements of this document to guide timely decision-making, raise awareness, and inspire further studies.

COVID-19 Stigma and Charismatic Social Relationship: A Legitimization Narrative of President Trump’s Status as a Charismatic Leader following a SARS-CoV-2 Infection Reported by the Portuguese Media

This concept paper aimed to understand how stigma, a concept usually associated with negative social relationships, in the context of a pandemic threat such as COVID-19 can, in some situations, structure a charismatic social relationship in a perceived positive association between stigma and a specific social characteristic. For this purpose, we used the example of the news selected and highlighted by several Portuguese media about the actions and messages developed by President Trump in the context of his infection with SARS-CoV-2 and the subsequent recovery process. These news reports gave visibility to a narrative that can be considered as reinforcing the legitimization of his condition as a charismatic leader in an electoral context marked by the pandemic threat. In conclusion, stigma associated with a pandemic health threat and generally linked to a negative social status can also reinforce admiration, trust, and belief in the charismatic leader by supporters and followers, as demonstrated with the plight of President Trump. Stigma can be a factor in social uplift in affirming an upward trajectory of social status and symbolic power for actors seen as ill, where stigma-motivated discrimination is experienced positively, unlike in most cases.

Digitainability—Digital Competences Post-COVID-19 for a Sustainable Society

The digitalization of societies, accelerated by the COVID-19 pandemic, is an unstoppable process. This paper seeks to answer the question: what post-COVID-19 digital competences are needed for a sustainable society? It also aims to analyze the digitalization processes in education for shaping a sustainable digital society. A bibliographic search was performed on some of the most relevant international databases of scientific literature and the selected documents were analyzed through a content analysis. It is concluded that digital education has experienced a strong increase, reinforced by COVID-19, shaping the digital presence in all dimensions of life. However, it is not sufficient to assume that the new generations are naturally engaged in and can master digital social sustainability. The results demonstrate the importance of literacy and the unavoidable promotion of sustainability in a digital society. However, this digitalization of the educational process poses several challenges: it requires both software and hardware conditions, as well as digital literacy as a result of a complex of literacies. It also implies that teachers and students change their standpoints and practices with the attainment of new teaching and learning competences in order to fight the digital divide and to foster the widest possible social inclusion for the promotion of sustainable society—digitainability.

Determinants of COVID-19 Mortality in Patients With Cancer From a Community Oncology Practice in Brazil.

PURPOSE: The COVID-19 pandemic remains a public health emergency of global concern. Determinants of mortality in the general population are now clear, but specific data on patients with cancer remain limited, particularly in Latin America. MATERIALS AND METHODS: A longitudinal multicenter cohort study of patients with cancer and confirmed COVID-19 from Oncoclínicas community oncology practice in Brazil was conducted. The primary end point was all-cause mortality after isolation of the SARS-CoV-2 by Real-Time Polymerase Chain Reaction (RT-PCR) in patients initially diagnosed in an outpatient environment. We performed univariate and multivariable logistic regression analysis and recursive partitioning modeling to define the baseline clinical determinants of death in the overall population. RESULTS: From March 29 to July 4, 2020, 198 patients with COVID-19 were prospectively registered in the database, of which 167 (84%) had solid tumors and 31 (16%) had hematologic malignancies. Most patients were on active systemic therapy or radiotherapy (77%), largely for advanced or metastatic disease (64%). The overall mortality rate was 16.7% (95% CI, 11.9 to 22.7). In univariate models, factors associated with death after COVID-19 diagnosis were age ≥ 60 years, current or former smoking, coexisting comorbidities, respiratory tract cancer, and management in a noncurative setting (P < .05). In multivariable logistic regression and recursive partitioning modeling, only age, smoking history, and noncurative disease setting remained significant determinants of mortality, ranging from 1% in cancer survivors under surveillance or (neo)adjuvant therapy to 60% in elderly smokers with advanced or metastatic disease. CONCLUSION: Mortality after COVID-19 in patients with cancer is influenced by prognostic factors that also affect outcomes of the general population. Fragile patients and smokers are entitled to active preventive measures to reduce the risk of SARS-CoV-2 infection and close monitoring in the case of exposure or COVID-19-related symptoms.

Dealing with lung cancer in the COVID-19 scenario (A review)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has caused the coronavirus disease 2019 (COVID-19), first appeared in December 2019 in Wuhan (China) and quickly spread worldwide and has since been assigned a pandemic status. This affected the worlds' social interactions, including within medical practices, thus interfering with routine treatments for a variety of diseases including cancer. Different studies have addressed the fact that patients with cancer are often immunocompromised, making them more susceptible to infections. Since COVID-19 frequently causes respiratory distress, patients with lung cancer are considered to be a high-risk group. Genes that have been indicated to mediate viral entry into host cells such as angiotensin-converting enzyme 2 and transmembrane protease serine 2 are expressed in the lung tissue, a fact that could partially explain COVID-19 pathogenesis and lung involvement. Therefore, the current study offers a disease overview including molecular aspects behind the infection and provide a perspective on already published Chinese data plus recommendations for the management of lung cancer patients according to the two main lung cancer types and stages: non-small cell lung cancer and small cell lung cancer. This review aimed to add to the collective effort of selecting the most appropriate guidelines to follow for the treatment of these patients. [ABSTRACT FROM AUTHOR] Copyright of Molecular & Clinical Oncology is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Dealing with lung cancer in the COVID-19 scenario (A review).

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has caused the coronavirus disease 2019 (COVID-19), first appeared in December 2019 in Wuhan (China) and quickly spread worldwide and has since been assigned a pandemic status. This affected the worlds' social interactions, including within medical practices, thus interfering with routine treatments for a variety of diseases including cancer. Different studies have addressed the fact that patients with cancer are often immunocompromised, making them more susceptible to infections. Since COVID-19 frequently causes respiratory distress, patients with lung cancer are considered to be a high-risk group. Genes that have been indicated to mediate viral entry into host cells such as angiotensin-converting enzyme 2 and transmembrane protease serine 2 are expressed in the lung tissue, a fact that could partially explain COVID-19 pathogenesis and lung involvement. Therefore, the current study offers a disease overview including molecular aspects behind the infection and provide a perspective on already published Chinese data plus recommendations for the management of lung cancer patients according to the two main lung cancer types and stages: non-small cell lung cancer and small cell lung cancer. This review aimed to add to the collective effort of selecting the most appropriate guidelines to follow for the treatment of these patients.

COVID-19 and Social Sciences

The COVID-19 pandemic (caused by the Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2) is having profound effects on all dimensions of life, such as the individual, social, cultural, public health, and economic dimensions [...]

Algorithms for testing COVID-19 focused on use of RT-PCR and high-affinity serological testing: A consensus statement from a panel of Latin American experts.

The COVID-19 pandemic has caused an unprecedented public health, social, and economic crisis. Improving understanding on available tests for detecting COVID-19 is critical for effective management of the pandemic. We proposed that a multidisciplinary expert panel can establish recommendations on ideal use of diagnostic tools, with a focus on RT-PCR and serological high-affinity antibodies (both IgM and IgG) tests for the Latin America region. STUDY DESIGN: A collaborative multidisciplinary panel of 5 recognized experts in Latin America (an infectious disease specialist, three pathologists, and an immunologist) was convened and supported by Roche Diagnostics to develop standard guidelines and an evidence-based document of best practices on the use of diagnostic tools for COVID-19. RESULTS: The authors reached consensus on the applicability of diagnostic tools to provide testing algorithms for the use of RT-PCR and serological high-affinity antibodies (both IgM and IgG) tests in three settings: 1) For asymptomatic subjects exposed to a SARS-CoV-2 infected person; 2) For epidemiological purposes and; 3) For symptomatic subjects. CONCLUSION: The serological high-affinity SARS-CoV-2 antibodies (both IgM and IgG) tests play a key role in COVID-19 diagnosis. These tests can be applied for suspected false-negative RT-PCR results and for individual determination of response. The use of these tests can also contribute greatly to public health strategies, such as population screening and supporting vaccination planning. Serological status for high-affinity antibodies (both IgM and IgG) should be performed ideally 21 days after potential infectious contact, given that the majority of exposed individuals will have seroconverted.

TEACHING, LEARNING AND EVALUATION IN THE CONTEXT OF THE PANDEMIC: PERCEPTIONS OF PROFESSORS OF FUTURE TEACHERS

The COVID-19 pandemic forced the change from face-to-face learning to distance learning, namely in initial teacher training. Another form of teaching, learning and student evaluation was created, using technological tools. In this context, we questioned the perceptions of professors in the initial teacher training courses at the University of Tras-os-Montes and Alto Douro (UTAD) about teaching, learning and assessment of students in the context of distance learning. To answer this question, we conducted a questionnaire, with closed questions, to these professors. From the data that was collected and analyzed, we could conclude that, for professors, teaching was carried out through synchronous classes and asynchronous moments of interaction on social networks, in which students' autonomous work and learning took on a relevant role. Additionally, for these professors, more structured formative evaluation was encouraged with distance learning.

The COVID-19 Contagion–Pandemic Dyad: A View from Social Sciences

The objective of this concept paper focuses on the relevance of the analytical potential of Social Sciences for understanding the multiple implications and challenges posed by the COVID-19 contagion–pandemic dyad. This pandemic is generating a global threat with a high number of deaths and infected individuals, triggering enormous pressure on health systems. Most countries have put in place a set of procedures based on social distancing, as well as (preventive) isolation from possible infected and transmitters of the disease. This crisis has profound implications and raises issues for which the contribution of Social Sciences does not seem to be sufficiently mobilised. The contribution of Social Sciences is paramount, in terms of their knowledge and skills, to the knowledge of these problematic realities and to act in an informed way on these crises. Social Sciences are a scientific project focused on interdisciplinarity, theoretical and methodological plurality. This discussion is developed from the systems of relationships between social phenomena in the coordinates of time and place, and in the socio-historical contexts in which they are integrated. A pandemic is a complex phenomenon as it is always a point of articulation between natural and social determinations. The space of the discourse on the COVID-19 pandemic can be understood as the expression of a coalition of discourses, i.e., the interaction of various discourses, combined in re-interpretative modalities of certain realities and social phenomena. The circumstantial coalitions of interests, which shape the different discursive records and actions produced by different agents of distinct social spaces, enable the acknowledgement and legitimation of this pandemic threat and danger, and the promotion of its public management.

The impact of the coronavirus disease 2019 pandemic on the utilisation of emergency urological services.

OBJECTIVES: To compare the number of patients attending the Urology Emergency Department (ED) of the Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics, the reasons for admission, the clinical severity under the Manchester triage system (MTS), and the need for emergency surgery or hospitalisation, during the coronavirus disease 2019 (COVID-19) pandemic and the equivalent period in 2019. PATIENTS AND METHODS: Data were collected from patients attending the Urology ED of the CHUP over 3 weeks, from 11 March to 1 April 2020, and from the same period in the previous year (from 11 March to 1 April 2019). RESULTS: During the pandemic, 46.4% fewer patients visited our urological ED (122 vs 263). There was no significant difference in the mean age or the number of old patients (aged ≥65 years) between the two periods. However, significantly fewer female patients sought emergency urological services during the COVID-19 pandemic period (32.7% vs 14.8%, P < 0.05). No significant differences were noted between different clinical severity groups under the MTS. In 2019, significantly less patients required hospitalisation. The most common reasons for admission, during both periods, were haematuria, renal colic and urinary tract infections. The authors recognise that the study has several limitations, namely, those inherent to its retrospective nature. CONCLUSION: COVID-19 significantly influenced people's urological care-seeking behaviour. Understanding the present situation is helpful for predicting future urological needs. Based on the results of this study, we have reason to speculate that people's requirements for urological services might grow explosively in the post-COVID-19 period. There should be further studies about the real state of long-term urological services and the consequences that this pandemic may have in terms of morbimortality not directly related to the severe acute respiratory syndrome coronavirus 2.

A qualidade do sono durante o distanciamento domiciliar na pandemia do COVID-19 na Amazônia ocidental

Introdução: A pandemia COVID-19 incitou restrições globais e sem precedentes ao comportamento da sociedade. O distanciamento domiciliar e as medidas de isolamento aplicadas durante a pandemia COVID-19 podem resultar em problemas na qualidade do sono. É uma medida importante para diminuir o risco de infecção do surto COVID-19. Objetivo: Investigar a existência de diferença entre a qualidade do sono antes e durante o distanciamento domiciliar imposto pela pandemia de Covid-19. Método: Pesquisa transversal baseada na web foi enviada por meio de diferentes mídias sociais convencionais visando coletar dados da população do estudo. O grupo avaliado foi composto por 124 sujeitos, sendo 57 do sexo masculino e 67 do sexo feminino da cidade de Rio Branco/AC. Para este estudo, foi utilizado o questionário do Índice de Qualidade do Sono de Pittsburgh (PSQI-BR) e um sóciodemográfico. Os voluntários receberam um link junto com a descrição e o objetivo do estudo. Por fim, a análise dos dados foi realizada no software SPSS 22.0. Resultados: A qualidade do sono piorou significativamente durante o distanciamento domicilia em quatro componentes do sono (qualidade subjetiva do sono, latência do sono, sonolência do sono e pontuação geral do PSQI). Durante o distanciamento social foi maior o sono ruim entre os entrevistados (OR = 5,68;IC 95% = 1,80–17,82;p=0,70). Conclusão: Os resultados indicaram que houve diferença significativa entre a qualidade do sono antes e durante o distanciamento domiciliar e o distúrbio do sono e a qualidade subjetiva do sono antes e durante o período do surto de COVID-19 foram os componentes que mais apresentaram piora no estado do sono.Alternate abstract: Introduction: the COVID-19 pandemic incited unprecedented global restrictions on society’s behavior. Home detachment and isolation measures applied during the COVID-19 pandemic can result in problems with sleep quality. It is an important measure to reduce the risk of infection from the COVID-19 outbreak. Objective: to investigate the existence of a difference between the quality of sleep before and during the home distance imposed by the Covid-19 pandemic. Methods: cross-sectional web-based survey was sent using different conventional social media to collect data from the study population. The evaluated group was composed of 124 subjects, 57 of whom were male and 67 were female from the city of Rio Branco / AC. For this study, the Pittsburgh Sleep Quality Index questionnaire (PSQI-BR) and a socio-demographic questionnaire were used. The volunteers received a link along with the description and purpose of the study. Finally, data analysis was performed using SPSS 22.0 software. Results: sleep quality worsened significantly during home distance in four sleep components (subjective sleep quality, sleep latency, sleep drowsiness and overall PSQI score). During social distance, poor sleep was greater among respondents (OR = 5.68;95% CI = 1.80–17.82;p = 0.70). Conclusion: the results indicated that there was a significant difference between the quality of sleep before and during home detachment and sleep disturbance and the subjective quality of sleep before and during the period of the outbreak of COVID-19 were the components that most worsened in the state of sleep

Effects of the social isolation generated by Covid-19 on the quality of life of the population in two Brazilian cities

Introdução: o COVID-19 é um vírus altamente transmissível e que estar causando problemas gravíssimos na saúde do mundo, gerando com isso, grandes problemas políticos e financeiros. Existem inúmeros fatores de risco relacionados a esta doença, que vai desde morbidades até questões sociais e familiares. Objetivo: avaliar os efeitos do isolamento social gerado pelo Covid-19 na qualidade de Vida na população de duas cidades Brasileiras. Método: estudo transversal. A pesquisa foi realizada em duas cidades diferentes da confederação brasileira. Uma em Santo André – SP e a outra em Rio Branco-Ac. Trata-se de uma pesquisa com uma plataforma online, utilizando a ferramenta do Google Formulários do drive para avaliar a qualidade de vida da população pelo protocolo SF-36. A seleção foi realizada de forma aleatória em ambos os grupos (Acre e São Paulo), tendo respectivamente 109 e 62 participantes neste primeiro momento. Resultados: em relação ao gênero, as mulheres estão em maior número participando na cidade de Santo André - SP do que em Rio Branco-AC, com (80,6% e 48,6%), respectivamente. Da mesma forma, em relação a faixa etária Santo André encontra-se com uma média de idade mais jovem do que em Rio Branco. Quando realizamos uma comparação das dimensões entre os dois estados realizando uma análise estatística de Mann-Whitney apareceram diferença estatística em três dimensões, que foram a capacidade funcional, a Dor e a vitalidade, apresentando nestes três domínios melhor qualidade de vida para a cidade de Rio Branco. Conclusão: a cidade de Rio Branco-Acre encontra-se com um escore positivo quando comparado com a cidade de Santo André - SP na maioria dos domínios analisados.Alternate abstract: Introduction: COVID-19 is a highly transmissible virus that is causing very serious problems in the health of the world, generating major political and financial problems. There are numerous risk factors related to this disease, ranging from morbidities to social and family issues. Objective: to evaluate the effects of the social isolation generated by Covid-19 on the quality of life in the population of two Brazilian cities. Methods: cross-sectional study. The research was carried out in two different cities of the Brazilian confederation. One in Santo André, São Paulo and the other in Rio Branco, Acre, both in Brazil. This is a survey with an online platform, using the drive’s Google Forms tool to assess the population’s quality of life through the SF-36 protocol. The selection was carried out randomly in both groups (Acre and São Paulo), having respectively 109 and 62 participants in this first moment. Results: regarding gender, women are in greater numbers participating in the city of Santo André, São Paulo than in Rio Branco, Acre, both in Brazil, with (80.6% and 48.6%), respectively. Likewise, in relation to the age group Santo André has an average age younger than in Rio Branco. When we compared the dimensions between the two states, performing a Mann-Whitney statistical analysis, statistical differences appeared in three dimensions, which were functional capacity, pain, and vitality, with better quality of life in these three domains for the city of Rio Branco. Conclusion: the city of Rio Branco, Acre, Brazil, has a positive score when compared to the city of Santo André, São Paulo, Brazil, in most of the domains analyzed.